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DAMPs can bind to and activate pattern recognition receptors on the surface of renal innate immune cells (such as macrophages and dendritic cells) and renal tubular epithelial cells, thereby activating downstream core pro-inflammatory signaling pathways such as NF-B, and inducing the massive secretion of pro-inflammatory factors including Tumor Necrosis Factor- (TNF-), Interleukin-1 (IL-1), and Interleukin-6 (IL-6) (Fu et al

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But amylin receptors and GLP-1 receptors are on slightly different groups of brain cells

Consuming smaller, more frequent meals rather than three large meals prevents excessive stomach distension

Brann et al., 2022)