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Proposed by GH-axis researchers to support lean body mass and body-composition changes, though this claim rests on GH and IGF-1's known physiological roles rather than on direct body-composition trials of CJC-1295 itself
Skin repair mechanisms and related signaling pathways are mediated by different genes, such as AQP3 (encoding a protein responsible for transporting water and glycerol, participating in the skin lipid metabolism, and regulating the differentiation and proliferation of keratinocytes in the wound-healing process), COL2A (encoding the main fibrous protein of skin ECM), FGF2 (encoding an angiogenic and mitogenic factor stimulating the cells proliferation and migration at the wound site), ITGB (encoding the main ECM adhesion transmembrane molecule), SEPTIN4 (encoding a GTP-binding protein involved in the morphogenesis and physiological functions of many cells, like skin cells), as well as FGF7, FGFR2, PPARD, and STAT3 8,9,10,11,12,13,14,15,16
[7] [9] Patients with a history of oxalate nephrolithiasis (kidney stones) or hyperoxaluria should avoid high-dose vitamin C administration, as ascorbic acid is metabolized to oxalate, which may precipitate stone formation or exacerbate renal impairment
hair thinning and follicle shrinkage
