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Serious Risks Rare but important: Pancreatitis: Occurs in a small percentage of patients

Disposition of drugs in cystic fibrosis

Mallajosyula V, Ganjavi C, Chakraborty S, McSween AM, Pavlovitch-Bedzyk AJ, Wilhelmy J, et al

Published data indicates most GI adverse events were transient, occurring primarily during the dose-escalation phase

Native IGF-1 added to cell culture media at the start of a 72-hour experiment will be substantially degraded and sequestered by the end of that window, even in serum-free conditions