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The GPX7 gene is located on chromosome 1p32 and is composed of 3 exons that encode a 187 amino acid precursor protein
KOETH R
10.1242/jcs.077149 J
In normal physiology, the majority of circulating IGF-1 is bound to IGFBP-3, forming a large ternary complex with the acid-labile subunit that prevents rapid clearance and buffers free IGF-1 within a tightly controlled range
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