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All other authors do not hold any competing interests

For first-time users, the published evidence base is strongest on topical at 1 to 2%

Neurotransmitters can be broadly divided into two main classes: small amino acids (e.g., aminobutyric acid [GABA], glutamate, aspartate, and glycine) and biogenic amines (e.g., dopamine, epinephrine, norepinephrine, serotonin, histamine, and acetylcholine) (11)