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Forward-Looking Statements: This article reflects information reviewed in July 2026

Sound mechanistic evidence supports the need for further research on the GLP1-RAs/SGLT2is combinations ability to modify specific risk outcomes, such as cardiovascular risk and the progression of diabetic kidney disease

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Although vascular endothelial growth factor (VEGF) is critical for developmental and pathological angiogenesis, recent evidence showed that autocrine VEGF could also contribute to the maintenance of vascular homeostasis (4)

Besides, the cost deters it from making its way into low- and middle-income countries, where people are not only most affected by obesity, but are also at risk of cardiovascular death, where it makes up nearly 80% of the global burden, according to the National Institutes of Health