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A single-copy gene, 36B4, was used as a genomic DNA control and copy number determination

Safety Profile PEG-MGF (pegylated mechano growth factor) demonstrates good tolerability in preclinical studies with minimal immunogenicity from pegylation modifications

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doi: 10.1038/s41416-019-0650-z 13 PietkiewiczDKlupczynska-GabryszakAPlewaSMisiuraMHoralaAMiltykWet al

The qualitative review found no consistent, recurrent, or biologically plausible pattern of congenital anomalies across case reports and case series