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GIP receptor signaling increases cAMP levels in the brain, which activates PKA and EPAC [102]
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Some stress markers of FF and serum, including malondialdehyde (MDA), 8-Oxo-2-deoxyguanosine (8-OHdG), and thiol oxidation, are associated with lower embryo quality, whereas higher Total Antioxidant Capacity (TAC) correlates with better fertilization rates and higher pregnancy success [75,76,77,78]
It has greater affinity to GIP receptors, rather than GLP-1 receptors, while its t of approximately 5 days allows once-weekly subcutaneous administration [9]
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