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Retatrutide adds a third receptor, glucagon, creating what researchers call a triple agonist

Semaglutide [1] $49 .99 per week, up to 0.6 mg, $74.99 per week above 0.6 mg Tirzepatide [2] $99 .99 $124.99 per week, above 8.0 mg [1] In the STEP 5 trial, participants for long-term treatment of adults with obesity, or overweight with at least one weight-related comorbidity, without diabetes, patients taking semaglutide (typically in doses of 2.4 mg once weekly) for weight management lost an average of about 15% of their body weight over 68 weeks

Common side effects can include nausea, vomiting, diarrhea, abdominal discomfort, and constipation, according to the FDA and major health systems

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