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For instance, a number of ongoing or completed trials are evaluating inhibitors of the PI3K-AKT-mTOR cascade, such as gedatolisib (NCT03065062) in advanced solid tumors, capivasertib (NCT04305496) in hormone receptor-positive breast cancer, and alpelisib (NCT02437318), which has shown efficacy in advanced breast cancer and is already approved for PIK3CA-mutated cases

This is particularly significant because visceral fat plays a key role in insulin resistance and inflammation

Serotonin syndrome (tremor, confusion, rapid heartbeat) is extremely rare with this combination at standard doses but warrants emergency care if it occurs

The signup and approval process is described as quick and simple by most users