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However, since no efforts are made to explain where the alleged apoptotic cells are located and the TUNEL assay always shows TUNEL-positive cells in the area of necrosis [56], it appears that these parameters are mainly being used to increase the amount of data in the manuscript rather than as a convincing mechanistic argument for apoptotic cell death [57]

Oxidative damage in synovial tissue is associated with in vivo hypoxic status in the arthritic joint

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However, the question often arises from niche studies or specific physiological contexts

Stoffel NU, von Siebenthal HK, Moretti D, Zimmermann MB