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Allergy or Mast-Cell Histamine Release Hives, itching, swelling, wheezing, rhinitis or reactions to allergens, temperature, medications or other triggers may reflect immune-cell activation rather than food histamine alone

Retatrutide has shown some of the highest weight loss percentages in early research among injectable treatments

So if retatrutides phase 3 trials finish in 2025 or early 2026, approval and market availability by late 2026 or 2027 is a plausible target assuming all goes well

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However, this may happen during the first few weeks of the treatment or after a dose increase