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Always use the lowest effective dose for the shortest duration
GLP-1R agonists exert neuroprotective effects in DPN by reducing neuronal apoptosis, inflammation, oxidative stress, mitochondrial dysfunction, and matrix remodelling
The monitoring schedule should follow each drug's individual requirements: annual magnesium and B12 levels for chronic PPI users, and periodic lipase/amylase plus gallbladder symptom assessment for Wegovy patients
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