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KPV, as a fragment of a naturally occurring hormone, is generally well-tolerated

No published trials have specifically enrolled participants with hepatic or renal impairment, so safety in these populations is unknown

10.1016/j.arr.2023.101936 46 WanX.GargN

As a result, the acne bacteria could concentrate instead on using their cellular machinery to churn out more compounds to attack our face and induce inflammation in acne. Indeed, as you can see here and at 3:53 in my video , without excess B12 on the skin (with B12 shown in green), the bacteria have to make most of it on their own at the expense of porphyrins (shown in red), which can trigger acne inflammation

Hair follicle stimulation